Symbol
Name
ID

Esr1
estrogen receptor 1 (alpha)
MGI:1352467

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Type II diabetes mellitus
Disease(s) Associated with ESR1	Diabetes mellitus	Type II diabetes mellitus
coronary artery disease
type 2 diabetes mellitus

Mouse Phenotypes

ovary hemorrhage

impaired granulosa cell differentiation

decreased gonadotroph cell number

increased gonadotroph cell number

decreased lactotroph cell number

decreased thymus weight

thymus hypoplasia

decreased thymocyte number

abnormal mammary gland morphology

abnormal mammary gland development

abnormal branching of the mammary ductal tree

abnormal mammary gland epithelium morphology

abnormal mammary gland duct morphology

mammary gland duct hyperplasia

abnormal mammary gland lobule morphology

abnormal mammary gland alveolus morphology

mammary gland alveolar hyperplasia

increased mammary gland ductal carcinoma incidence

abnormal prostate gland branching morphogenesis

abnormal seminal vesicle morphology

absent endometrial glands

decreased endometrial gland number

enlarged endometrial glands

abnormal ovary morphology

absent corpus luteum

decreased corpora lutea number

abnormal ovarian follicle morphology

abnormal granulosa cell morphology

absent mature ovarian follicles

abnormal ovarian follicle number

decreased primary ovarian follicle number

decreased primordial ovarian follicle number

increased tertiary ovarian follicle number

increased atretic ovarian follicle number

abnormal ovarian folliculogenesis

impaired ovarian folliculogenesis

abnormal tertiary ovarian follicle morphology

abnormal theca cell layer morphology

increased theca cell number

ovarian follicular cyst

ovary cyst

abnormal testis morphology

abnormal rete testis morphology

dilated rete testis

abnormal seminiferous tubule morphology

abnormal seminiferous tubule epithelium morphology

dilated seminiferous tubule

seminiferous tubule degeneration

abnormal testis weight

decreased testis weight

small testis

testicular atrophy

abnormal pituitary gland physiology

abnormal thymus physiology

abnormal lactation

abnormal prostate gland physiology

Availability

Mouse Genotype

Esr1^tm1.1Gust/Esr1^tm1.1Gust

Esr1^tm1.1Ics/Esr1^tm1.1Ics

Esr1^tm1.1Mma/Esr1^tm1.1Mma

Esr1^tm1.1Ohl/Esr1^tm1.1Ohl

Esr1^tm1Geog/Esr1^tm1Geog

Esr1^tm1Ksk/Esr1^tm1Ksk

Esr1^tm2.1Gsc/Esr1^tm2.1Gsc

Esr1^tm3.1Ksk/Esr1^tm3.1Ksk

Esr1^tm4.2Ksk/Esr1^tm4.2Ksk

Esr1^tm5.1Ksk/Esr1^tm5.1Ksk

Esr1^tm1.1Lja/Esr1⁺

Esr1^tm1Ksk/Esr1⁺

Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Esr1)#Paf/0

Tg(MMTVtTA)1Mam/0
Tg(tetO-Esr1)#Paf/0

Esr1^tm1.2Awo/Esr1^tm1.2Awo
Tg(Cga-cre)1Awo/0 (conditional)

Esr1^tm1.2Awo/Esr1^tm1.2Awo
Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ (conditional)

Esr1^tm1.2Mma/Esr1^tm1.2Mma
Tg(Cga-cre)3Sac/0 (conditional)

Esr1^tm1.2Mma/Esr1^tm1.2Mma
Tg(Cyp17a1-icre)AJako/0 (conditional)

Esr1^tm1Gsc/Esr1^tm1Gsc
Tg(Camk2a-cre)2Gsc/0 (conditional)

Esr1^tm1Sakh/Esr1^tm1Sakh
Tg(MMTV-cre)4Mam/? (conditional)

Esr1^tm1Sakh/Esr1^tm1Sakh
Tg(Wap-cre)11738Mam/? (conditional)

Esr1^tm1Syeh/Esr1^tm1Syeh
Tmem163^{Tg(ACTB-cre)2Mrt}/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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